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After a few years of Cymbalta I noticed that I never felt good anymore--particularly that I never woke up feeling refreshed. I also noticed I rarely remembered dreaming, which was not the case before Cymbalta. I took 3mg melatonin and the difference the first night was astonishing. I dreamed and awoke feeling good. Mild, brief grogginess went away after a few nights. The effects did seem to become less noticeable after taking for a week or so, but I still find it very beneficial. Falling asleep is not my problem; it's un-restful sleep due to effects of Cymbalta, and the melatonin really helps.



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For headache, 2-10 milligrams of melatonin has been taken by mouth nightly for 14 days to eight weeks.

Until its identification in plants in 1987, melatonin was for decades thought to be primarily an animal neurohormone.

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Use of blue-blocking goggles the last hours before bedtime has also been advised for people who need to adjust to an earlier bedtime, as melatonin promotes sleepiness.

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Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity.

Participants received standard radiation treatment with or without 20 mg daily of melatonin.

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