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Additional eligibility criteria were a history of chronic heart failure and receipt of an oral loop diuretic for at least 1 month before hospitalization, at a dose between 80 mg and 240 mg daily in the case of furosemide and an equivalent dose in the case of a different loop diuretic (20 mg of torsemide or 1 mg of bumetanide was considered to be equivalent to 40 mg of furosemide).

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Because of the possibility for adverse reactions in nursing infants from spironolactone, a choice should be made whether to stop nursing or to stop use of spironolactone.

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