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Statins lower cholesterol by preventing the liver from synthesizing new cholesterol, while Zetia lowers cholesterol by preventing the intestine from absorbing cholesterol into the blood stream.
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Articles were removed if they were clinical trials, case studies, reviews, or if they required specialized samples, techniques, or equipment that would be difficult or impossible to obtain.
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Treating high blood cholesterol along with a low-fat, low-cholesterol diet.
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In a 2-week clinical study in 18 hypercholesterolemic patients, ZETIA inhibited intestinal cholesterol absorption by 54%, compared with placebo.
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In clinical trials that led to Vytorin's approval in 2004, the combined benefits of a statin, which inhibits cholesterol production in the liver, and Zetia, which keeps the substance from being absorbed in the intestine, knocked down the level of LDL cholesterol about 20 percent more than Zocor could by itself.
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